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Description
A Practical Approach to Quantitative Validation of Patient-Reported OutcomesCondition: BRAND NEW ISBN: 9781119376378 Year: 2022 Publisher: John Wiley & Sons Inc (US) Description: A Simulation Based Guide Using SAS In A Practical Approach to Quantitative Validation of Patient Reported Outcomes, two distinguished researchers, with 50 years of collective research experience and hundreds of publications on patient centered research, deliver a detailed and comprehensive exposition on the critical steps required for quantitative
Condition: BRAND NEWISBN: 9781119376378
Year: 2022
Publisher: John Wiley & Sons Inc (US)
Description:
A Simulation-Based Guide Using SAS
In A Practical Approach to Quantitative Validation of Patient-Reported Outcomes, two distinguished researchers, with 50 years of collective research experience and hundreds of publications on patient-centered research, deliver a detailed and comprehensive exposition on the critical steps required for quantitative validation of patient-reported outcomes (PROs). The book provides an incisive and instructional explanation and discussion on major aspects of psychometric validation methodology on PROs, especially relevant for medical applications sponsored by the pharmaceutical industry, where SAS is the primary software, and evaluated in regulatory and other healthcare environments.
Central topics include test-retest reliability, exploratory and confirmatory factor analyses, construct and criterion validity, responsiveness and sensitivity, interpretation of PRO scores and findings, and meaningful within-patient change and clinical important difference. The authors provide step-by-step guidance while walking readers through how to structure data prior to a PRO analysis and demonstrate how to implement analyses with simulated examples grounded in real-life scenarios.
Readers will also find:
A thorough introduction to patient-reported outcomes, including their definition, development, and psychometric validation
Comprehensive explorations of the validation workflow, including discussions of clinical trials as a data source for validation and the validation workflow for single and multi-item scales
In-depth discussions of key concepts related
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4.5 ★★★★★
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★★★★★ 5
By far ... the SAFEST and most DURABLE bone for dogs that are hardy chewers!
Flavor Name: Beef, Size: Large
After searching high and low for a NON-TOXIC, DURABLE and truly SAFE dog bone, I finally found the large, beef-flavored, HARD version of the BetterBone for my year-plus-old rescue (Carolina Dog).
1 - it's made of all NATURAL food-grade materials (cellulose from plant cell walls) ... which means no nylon, no GMOs, and no other artificials materials so it doesn't event stain your flooring. My girl loves the tasty beef flavor.
2 - the wishbone DESIGN is genius because it gives her 3 ends to choose from (nubs v raised edges v smooth) and ample ways to stabilize it on the floor with her paws.
3 - it is uber DURABLE in standing up to the hardiest of chewers (my girl gnaws on hers daily and sometimes even multiple 10-minute sessions per day). It works great to clean and reduce tartar on her teeth. The biggest surprise was that it took 6 months for her to gnaw it down to a size that was no longer safe for her (i.e. a potential choking hazard), so I donated it to a lady with tiny dogs at the dog park. At $20 per large bone, it's a good value.
4 - and most importantly, ... it is super SAFE. It degrades in tiny little pieces that could not possibly cause a choking hazard, and being all natural (i.e. no nylon - which most bones do have), there is no worry if she does ingest some of the particles. They vacuum up with ease.
The large bone weighs in at just over 12 ounces so it's kinda' heavy (9.25" long x 5" wide x 2" thick), but my 56 lb girl has no problem picking it up in her mouth before she hops up on the couch with me or into her bed.
Thank you BetterBone for making a superior product that is healthy, safe and fun for my pup!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 15, 2025
★★★★★ 5
Great chew
Flavor Name: Beef, Size: Large
Excellent! My super chewer loves it!
He chews it everyday and it holds up!
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Reviewed in the United States on May 1, 2026
★★★★★ 4
Decent durability
Flavor Name: Beef, Size: Small
My super chewer pit bull mix loved these! They lasted several weeks.
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Reviewed in the United States on April 16, 2026
★★★★★ 5
Best chew toy we have ever purchased.
Flavor Name: Classic, Size: Large
My moderately active 80lb Lab - Pit mix has been steadily working on this bone for over a year. He doesnt chew it every day but he does regularly chew it for 30 or more minutes at a time. He has only been chewing on the smooth end, and the only wear it shows is a slight thinning and some grooved tooth marks. It has not had any chunks come off, and has never developed any sharp edges that make it hard to play with.
It has never smelled or gotten slimy. It has never triggered resource guarding with him, but he likes it enough that presenting it to him will often get him to settle down and chew when he is in a rambunctious mood. Its size and shape allows him to hold the textured Y end with his paws while chewing on the smooth end.
All in all a fantastic toy!
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Reviewed in the United States on February 15, 2026
★★★★★ 5
Happy Doggo
Flavor Name: Beef, Size: Small
He immediately loved it. He doesn't take to bones quickly, but this one caught his eye. He's a 35 lb shepherd mix, and loves antlers, and chews pretty hard. I love that it doesn't smell, and havne't seen or noticed flakes. Overall would recommend.
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Reviewed in the United States on April 6, 2026
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