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Description
CD30 Recombinant Rabbit mAb (SDT-216-2)Product Specification Host Rabbit Antigen CD30 Synonyms Ki 1, KI 30 Ber H2, Tumor necrosis factor receptor superfamily member 8, TNFRSF8, CD30L receptor, Ki 1 antigen, Lymphocyte activation antigen CD30 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane Accession P28908 Clone Number SDT 216 2 Antibody Type Recombinant mAb Application IHC P, ICC, ICFCM Reactivity Hu, Ms Purification Protein A Concentration 0. 25 mg ml Physical Appearance
Product Specification
| Host | Rabbit |
| Antigen | CD30 |
| Synonyms | Ki-1, KI-30 Ber-H2, Tumor necrosis factor receptor superfamily member 8, TNFRSF8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane |
| Accession | P28908 |
| Clone Number | SDT-216-2 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | |
| ICC | 1:250 | |
| ICFCM | 1:25 |
Background
CD30 is a transmembrane protein from the tumour necrosis factor receptor superfamily. It is expressed on a small subset of activated T and B lymphocytes, and various lymphoid neoplasms. CD30 is a particularly treatment target because its levels are high in tumours but low in healthy tissues. Several therapeutic strategies targeting CD30 have been developed, including monoclonal antibodies, conjugated antibodies (combination of brentuximab vedotin with chemotherapy or immunotherapy), bispecific antibodies and cell and gene therapies, such as anti-CD30 CAR-T cells in particular [PMID: 37170397].
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