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Description
K9 Advantix II XL Dog Flea, Tick & Mosquito Treatment & PreventionK9 Advantix II Extra Large Dog is the veterinarian recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing
K9 Advantix II Extra Large Dog is the veterinarian-recommended formula that helps defend your dog against five pests: fleas, ticks, mosquitoes, biting flies and lice. And unlike other treatments, K9 Advantix II kills and repels fleas, ticks and mosquitoes. K9 Advantix II topical treatment gets straight to work killing fleas on dogs within 12 hours of initial application. This formula stops existing flea infestations and prevents new ones by killing adult fleas on contact so they can’t lay eggs and they don’t have to bite your dog to die. Fleas, ticks, mosquitoes and other pests not only cause discomfort; they may also transmit disease. Monthly use of K9 Advantix II is important to protect your dog against fleas that may cause transmission of tapeworms. This formula also kills fleas which may cause Flea Allergy Dermatitis and flea bite anemia. That’s why K9 Advantix II Extra Large Dog topical, spot-on formula makes application simple - going on in seconds. It's easier than a flea collar and there are no hard-to-swallow pills. You’ll also love that K9 Advantix II is fragrance-free and waterproof after 24 hours of application. Check the product label for information on application and potential side effects. K9 Advantix II pest protection is effective on both indoor and outdoor dogs. Your dog should be at least 7 weeks old and weigh over 55 lbs. to use K9 Advantix II Extra Large Dog. For the ultimate convenience in care, K9 Advantix II is available over the counter – no prescription needed. And, you can stock up with 2-dose, 4-dose and 6-dose packs so you never miss a monthly treatment. Once K9 Advantix II is applied, your dog is ready to get right back to big-pup cuddles and racing around the park. K9 Advantix II Extra Large Dog is a trademark of Elanco or its affiliates.
Key Features
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K9 Advantix II Extra Large Dog 30-day treatment & prevention protects dogs over 55 lbs. from fleas, ticks, mosquitoes, biting flies and lice
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Kills fleas within 12 hours of application
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Vet-recommended formula kills & repels on contact so fleas don’t have to bite your dog to die
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Easy-to-apply topical treatment is fragrance-free and waterproof after 24 hours
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No prescription needed
Directions for Use
Use only on dogs. DO NOT USE ON CATS or other animals. Do not apply to dogs weighing less than 4 lbs. Remove applicator tube from the package. Use scissors and peel down foil. Hold applicator tube in an upright position. Pull cap off tube. Turn cap around and place other end of cap back on tube. Twist cap to break seal, then remove cap from tube. The dog should be standing for easy application. Evenly apply entire contents of the tube along the top of the dog's back, from the shoulder down to the base of the tail. The number of spots depends on the size and weight of your dog (please refer to the product label). At each spot, part the hair until skin is visible. Place the tip of the tube on the skin and gently squeeze to expel a portion of the solution on the skin. Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the dog. Do not get this product in your dog’s eyes, or allow your dog to ingest this product.
Storage Instructions
Store in a cool, dry place inaccessible to children and pets. Protect from freezing.
Active Ingredients
Imidacloprid, Permethrin, Pyriproxyfen
Product Form
- Topical
Pet Size
- Extra Large
Pet Lifestage
- 7 weeks and older
Pet Weight
Over 55 lbs
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy
4.4 ★★★★★
Based on 237 reviews
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Product Reviews
★★★★★ 5
For the love of a dog!
Color: Blue, Style: Tootiez Hedgehog, Color: Blue, Style: Tootiez Hedgehog
Okay, first - this toy is a hoot. When you first get it and hear it's cute grunting/tooting sound, you can't help but grin and think, Yup! That sounds like somebody in here just tooted! Which for some reason always does seem to be a bit funny, doesn't it? And you'll probably find yourself chuckling a little and saying, Oh how cute. After that, the next logical step is you'll introduce the toy to your dog. And then, depending on your dog's particular personality, you may soon discover (as we did) the amazing love/hate relationship a human can develop with a simple dog toy.
We have a 1-yr-old standard poodle whom we named Kenda. And yes, he is named after Joe (for any of you ID fans out there). His official AKC registered name is Lieutenant Kenda, Home Inside Hunter. Corny? No doubt. But it truly seemed an appropriate name for him, because this is the first dog we've ever owned that actually LOVES to play with dog toys and will endlessly hunt them down throughout the house. No toy, however well hidden, stands a chance with this determined toy hunter. As Joe might say, he WILL find you! :) His toys are his friends, and he is fiercely devoted to them.
Enter the adorable little rubber hedgehog with his even more adorable "toot". The moment Kenda laid eyes (or ears?) on this little guy, all other toys were forgotten. It was love at first sight. So much so that within a few hours of him playing with this toy to the exclusion of all others, we decided to give him a name. We call him "Blue" (I know, we're so creative). Blue immediately became Kenda's best friend - or at least his best toy. He played with him constantly. He bit him, he wrestled with him, he chewed on him. He brought Blue to us and, if we were sitting down, very carefully placed this slobbery ball of rubber in our laps, as if asking, Can we play catch with Blue? Huh? Pretty please?? Sometimes we did, sometimes we didn't. On those occasions when we didn't, he would play catch with himself, picking Blue up in his mouth, swinging his head, and tossing him across the kitchen; then running/sliding across the kitchen floor to retrieve him on the other side of the room. In the beginning, if Blue was nowhere in sight (and with dogs, out of sight is usually out of mind), the hubby and I would get a kick out of saying, "Kenda, where's Blue?!" Just for the enormous fun of watching a 55-pound poodle suddenly leap a foot in the air, scramble his legs mid-air like Fred Flintstone getting his car started, then half running/half sliding across the kitchen hardwood floor in a desperate effort to find his beloved Blue. Oh, how we entertained ourselves in those early days watching Kenda with his Blue. And through it all, through every bite, squeeze, toss, push, throw, and chew of this toy.......the toot. The grunt. Okay, let's call it what it really sounds like, folks: a FART, okay? There, I've said it. It sounds like your grandpa just passed gas - bigtime. Funny? At first, yes. Hilarious. But a thousand times a day? Over and over and over? While you're trying to talk on the phone? While you're trying to have conversation with each other over coffee at the end of the day? Sometimes for an hour NON-STOP? Well, let's just say the humor of it all began to elude us a bit. And therein lies our love/hate relationship with this adorable little toy.
We thought we'd died and gone to heaven one day when Blue stopped tooting. Turns out Kenda had chewed on him so much his tooter (located rather anatomically correctly in his tushie) had fallen out. Or rather IN, since it was now in Blue's tummy. Poor Blue, he couldn't make noise anymore, and although Kenda kept playing with him you could tell he was confused as to why his little buddy had fallen silent and wouldn't "talk" to him anymore. And as much as the hubby and I were enjoying the tooting reprieve, we couldn't take it. By the third silent day, I could almost feel the invisible hands of Amazon coaxing me toward my computer, gently urging me to buy another Blue. But I resisted, folks. I did NOT buy another Blue. I bought TWO more Blues! One for now, and one for that possible future day when this Blue, too, falls silent. Why? Because ... well, because it's BLUE! He's practically a member of the family now. The dog loves Blue, and we love the dog. I guess it's that simple.
My final word on this dog toy? It's adorable. It's well made and will hold up to a ton of play and chewing. His tooter may not survive as long; I guess that remains to be seen. And if your dog is anything like mine, well then your sanity may take a hit as well. But if your dog loves his little hedgehog buddy as ours does, and if you love your dog (and you know you do!), then you might decide your sanity is worth the risk.
Two thumbs way, WAY up!
P.S. Blue now has a friend. We just bought the pink sheep. Kenda is in 7th heaven. Our house sounds like a retirement home after a chili bean supper. And yes, we named him "Pink". I told you - we are nothing if not creative.
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Reviewed in the United States on June 6, 2018
★★★★★ 5
My Dog's All-Time Favorite Toy
Color: Pink, Style: Grunt Sound
The first one of these I ever got her was at Petco on sale for $1 - best $1 ever!
The reviews are right, though. The toy doesn't last forever and it's not good for aggressive chewers. In my opinion, however, that doesn't make it a bad toy. Here's why:
Aggressive chewers comments: Getting my sister's French Bulldog a stuffed toy (that's shredded in 5 minutes), compared to my Pitbull who does not tear up any toys, but is a stronger chewer when it comes to bones. My pup does not tear this up at all, but my sister's dog would. My point is: Don't get your dog a soft toy if your dog ruins soft toys.
Regarding the not long-lasting comments: the honking noise mechanism inside eventually pops inside the hole, rendering it honkless. Ours lasted about 6 months. It's pretty much impossible to fix unless you want to trouble yourself to fix it for 1 good honk each fix. I would, but I do also have a job to get to. My dog does still carry it around in it's noiseless state, but she doesn't play with it with the same enthusiasm.
How did I resolve this? I bought her 5 😂 She's only on her second, but I decided to stock it because they were on sale for $5.10 - I don't think I will get rid of any of them. I will just let her play with them on rotation until they fall apart.
Besides all that, my dog just simply loves this toy. I have never seen her so happy & playful with a toy. I can't promise this for your dog, as I can only tell you about mine.
We even have a "Sheepy" song.
[I have not been paid or given free Sheeps - my Sweet Pea just really loves her Sheepy]
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Reviewed in the United States on March 26, 2024
★★★★★ 5
Loud! Just Like She Likes It
Color: Hedgehog, Style: Big Squeak Hedgehog
My Great Dane loves this noisy toy. She prefers squeaky toys with loud, unusual squeakers. (I need to invest in earplugs.) She's not an agressuve chewer or rough player so this should last a long time. Like most squeaky toys she has, the squeaker wears out before the physical toy does and once the noise is gone she won't play with it any more. If others have a similar issue...check with your local animal shelter. Some (not all) will disinfect used toys for the dogs in their care.
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Reviewed in the United States on November 1, 2025
★★★★★ 5
Good toy
Color: Gator, Style: Accordionz (Grunt Sound)
Fun toy, holding up really well.
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Reviewed in the United States on June 1, 2026
★★★★★ 1
Fun while it lasts…
Color: Pink, Style: Grunt Sound
Fun while it lasts. Doesn’t last very long. This is our third one and last maybe a few weeks. The part that makes noise comes detached inside which causes to toy to no longer make noise, but also can be dangerous if it comes out.
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Reviewed in the United States on June 11, 2026